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It has long been the practice to set apart a group of diseases of the brain and spinal cord in which destruction of myelin (demyelination) is a prominent feature To de ne these diseases precisely is dif cult, for the simple reason that there is probably no disease in which myelin destruction is the exclusive pathologic change The idea of a demyelinative disease is, more or less, an abstraction that serves primarily to focus attention on one of the more striking and distinctive features of one group of pathologic processes The commonly accepted pathologic criteria of a demyelinative disease are (1) destruction of the myelin sheaths of nerve bers with relative sparing of the other elements of nervous tissue, ie, of axons, nerve cells, and supporting structures, as re ected by a relative lack of wallerian or secondary degeneration of ber tracts; (2) in ltration of in ammatory cells in a perivascular and particularly paravenous distribution; (3) a distribution of lesions that is primarily in white matter, either in multiple small disseminated foci or in larger foci spreading from one or more centers A classi cation of the demyelinative diseases is presented in Table 36-1 The diseases included in this classi cation conform approximately to the criteria enumerated above Like all classi cations that are not based on etiology, this one has its shortcomings in that it is somewhat arbitrary In some of the diseases here classi ed as demyelinative, notably Schilder disease and necrotizing hemorrhagic leukoencephalitis and even multiple sclerosis, there can be a severe degree of damage to axis cylinders and vascular structures as well as to myelin Contrariwise, a number of diseases in which demyelination is a prominent feature are not included In some cases of anoxic encephalopathy, for example, the myelin sheaths of the radiating nerve bers in the deep layers of the cerebral cortex or in ill-de ned patches in the convolutional and cenTable 36-1 Classi cation of the demyelinative diseases I Multiple sclerosis (disseminated sclerosis) A Chronic relapsing encephalomyelopathic form B Acute multiple sclerosis C Diffuse cerebral sclerosis (Schilder disease and concentric sclerosis of Balo) II Neuromyelitis optica (Devic disease) III Acute disseminated encephalomyelitis A Postinfectious: following measles, chickenpox, smallpox, mumps, rubella, in uenza, and other viral and some bacterial infections (Mycoplasma, Rickettsia) B Following rabies or smallpox and rarely other types of vaccination (postvaccinal) IV Acute and subacute necrotizing hemorrhagic encephalitis A Acute encephalopathic form (Hurst hemorrhagic leukoencephalitis) B Subacute necrotic myelopathy 771.

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Thus, the secondderivativetells us how fast the slopeis changingIt is commonlyrefened to as the cun,ature,because high value for the secondderivativemeanshigh curvature a Finallypartialderivatives usedfor lunctionsthat depend morethanonevariable are on Partialderivativescan be thoughtof as taking the derivativeof the functionat a pointwith For example,given a function/ that depends both r all but one variableheld constant on y, the partial derivativeof/with respectto{ at an arbitrarypoint (x, 1,)is detined and as

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Prints the version and configuration information for the Perl interpreter If the optional var is supplied, it prints out only the configuration information for the specified element as discovered via the Config module Here is the default output from the function:

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tral white matter are destroyed, while most of the axis cylinders are spared A relatively selective degeneration of myelin may also occur in some small ischemic foci due to vascular occlusion or in larger con uent areas, as is the case in Binswanger disease (see Chap 34) In subacute combined degeneration (SCD) of the spinal cord associated with pernicious anemia and in tropical spastic paraparesis (TSP), a demyelinating spinal cord disease, myelin may be affected earlier and to a greater extent than axis cylinder The same is true of progressive multifocal leukoencephalopathy (PML), central pontine myelinolysis, and Marchiafava-Bignami disease Some of these disorders and several others are no longer classi ed as demyelinative because their etiology has been established Also, for reasons that will become clear in subsequent discussion, the chronic progressive leukodystrophies of childhood and adolescence (eg, globoid body, metachromatic, and adrenal leukodystrophies), while clearly diseases of myelin, are set apart and called dysmyelinative because of their unique genetic and morphologic features and are discussed in Chap 37 Occupying an uncertain place in this nosology are demyelinative lesions associated with connective tissue diseases or merely with autoantibodies directed against DNA or phospholipids Again, the central nervous system (CNS) lesions may be multiple and cannot easily be distinguished radiologically from multiple sclerosis (MS) But, as noted further on, their nature is uncertain, and some are clearly due to a vasculopathy Excluded from discussion in this chapter are demyelinative diseases of the peripheral nerves Although they share a number of pathologic features with demyelinating diseases of the CNS, they are described with diseases of the peripheral nervous system in Chap 46 In the language of neurology, therefore, the term demyelination has acquired a special meaning; if it is to retain its value, it should be used in the restricted sense indicated above and not as a synonym for any destructive process of nerve bers or cerebral white matter or for inherent and inherited defects in myelin, even though the lesions may look alike in a section stained for myelin.

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